Activity, delivery, and diversity of Type VI secretion effectors
نویسندگان
چکیده
منابع مشابه
Type VI Secretion Effectors: Methodologies and Biology
The type VI secretion system (T6SS) is a nanomachine deployed by many Gram-negative bacteria as a weapon against eukaryotic hosts or prokaryotic competitors. It assembles into a bacteriophage tail-like structure that can transport effector proteins into the environment or target cells for competitive survival or pathogenesis. T6SS effectors have been identified by a variety of approaches, inclu...
متن کاملMarker for type VI secretion system effectors.
Bacteria use diverse mechanisms to kill, manipulate, and compete with other cells. The recently discovered type VI secretion system (T6SS) is widespread in bacterial pathogens and used to deliver virulence effector proteins into target cells. Using comparative proteomics, we identified two previously unidentified T6SS effectors that contained a conserved motif. Bioinformatic analyses revealed t...
متن کاملThe type VI secretion system: translocation of effectors and effector-domains.
A number of prominent Gram-negative bacteria use the type VI secretion system (T6SS) to transport proteins across the bacterial envelope. Rapid progress is being made in elucidating the structural components of the T6SS apparatus, and a few effectors have been reported to pass through it. However, this is not the complete story: a family of T6SS proteins, the VgrGs, share structural features wi...
متن کاملType VI secretion system
Bacteria employ a variety of tools to survive in a competitive environment. Salomon and Orth describe one such tool-the Type 6 Secretion Systems used by bacteria to deliver a variety of toxins into competing cells.
متن کاملType VI secretion system MIX‐effectors carry both antibacterial and anti‐eukaryotic activities
Most type VI secretion systems (T6SSs) described to date are protein delivery apparatuses that mediate bactericidal activities. Several T6SSs were also reported to mediate virulence activities, although only few anti-eukaryotic effectors have been described. Here, we identify three T6SSs in the marine bacterium Vibrio proteolyticus and show that T6SS1 mediates bactericidal activities under warm...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2020
ISSN: 0950-382X,1365-2958
DOI: 10.1111/mmi.14648